Human disease locus discovery and mapping to molecular pathways through phylogenetic profiling
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چکیده
منابع مشابه
Human disease locus discovery and mapping to molecular pathways through phylogenetic profiling
Genes with common profiles of the presence and absence in disparate genomes tend to function in the same pathway. By mapping all human genes into about 1000 clusters of genes with similar patterns of conservation across eukaryotic phylogeny, we determined that sets of genes associated with particular diseases have similar phylogenetic profiles. By focusing on those human phylogenetic gene clust...
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15 صفحه اولMolecular Biology Through Discovery
Last week we eavesdropped on a meeting March 1960 in Sydney Brenner's apartment, in which Francois Jacob recounted recent results from Institut Pasteur. It was called Part I (Crick's Story), because I envisioned three parts: Part I. The world as seen through the eyes of Francis Crick, focusing on his view of an article by Belozersky and Spirin Part II. The world as seen through the eyes of Fran...
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ژورنال
عنوان ژورنال: Molecular Systems Biology
سال: 2013
ISSN: 1744-4292,1744-4292
DOI: 10.1038/msb.2013.50